Convenient Synthesis of Benzothiazoles and Benzimidazoles.
Benzotriazole (BTA) is a heterocyclic compound containing three nitrogen atoms, with the chemical formula C 6 H 5 N 3. This aromatic compound is colorless and polar and can be used in various fields. Structure. Benzotriazole features two fused rings. Its five-membered ring can exist in tautomers A and B, and the derivatives of both tautomers, structures C and D also can be produced. Various.
Chapter 3 contains work towards the synthesis of the benzothiazole containing natural product erythrazole A. The first half of the Chapter focuses on the formation of the heterocyclic core, originally attempting to use a biomimetic strategy but switching to an approach utilising the oxidative cyclisation of thioamides. The second half of the Chapter discusses many routes to synthesise and.
Benzothiazoles have played an important role in the field of biochemistry and medicinal chemistry due to their highly pharmaceutical and biological activity. The development of synthetic processes is undoubtedly one of the most significant problems facing researchers. In this review paper, we provided recent advances in the synthesis of benzothiazole compounds related to green chemistry from.
Benzothiazole is a privileged bicyclic ring system. Due to its potent and significant biological activities it has great pharmaceutical importance; hence, synthesis of this compound is of considerable interest. The small and simple benzothiazole nucleus if present in compounds involved in research aimed at evaluating new products that possess interesting biological activities.
Synthesis and characterization of Schiff’s bases derived from 2-amino benzothiazole, 2-amino-6-chloro benzothiazole and 2-amino-6-bromo benzothiazole with o-Vanillin were done in the present work. The synthesized compounds were tested for anti-oxidant activities by DPPH and ABTS assay. All the compounds showed good.
Synthesis of o-Phenyl-benzothiazole from o-Aminothiophenol and Benzaldehyde; 2 g of the previously prepared o-aminothiophenol and 1.695 g of benzaldehyde are charged into a 25 ml Erlenmeyer flask with 15 ml of glycerol. The reaction is heated for one hour. Afterwards, water is added until precipitate no longer fell out of solution; the precipitate is purified via recrystallization in hot.
The electrophilic reactions (nitration, bromination, hydroxymethylation, formylation, acylation) and radical substitution reactions (nitration, arylation) of 2-(2-furyl)benzothiazole have been studied. It was found that all of the reactions occur at position 5 of the furan ring. Only nitration in PPA gave the 5',6-dinitro derivative. Quantum-chemical calculation data for the electron density.